沈兴

发布者:食品学院313发布时间:2026-10-21浏览次数:24

姓名

沈兴

性别

女

毕业院校

华南理工大学

政治面貌

党员

学历

博士研究生

学位

工学博士

邮箱地址

shenxing325@163.com

通讯地址

广州市天河区五山路华南农业大学食品学院

职称

教授

所在院系

食品科学系

个人简介

沈兴,博士,教授,博士生导师,获广东省珠江学者青年学者、华南农业大学教学名师等称号。博士毕业于华南理工大学,之后于华南农业大学食品学院工作至今。研究方向为食品安全相关的生物分子识别与快速检测技术等,近两年主要围绕抗体与小分子药物的相互作用机制、CRISPR-Cas新型检测体系、食品安全与食品真实性快速鉴别等方面开展了系列研究。获得2023年广东省科技进步奖一等奖(排名第2),主持国家自然科学基金国际(地区)合作与交流项目、面上项目、青年基金以及国家重点研发计划项目子课题、广东省重点研发计划项目课题等。在国际及国内权威期刊发表论文50余篇,其中以第一作者或通讯作者在Food Chem、J Agr Food Chem、JHM、Food Control等杂志发表SCI论文近30篇。任《食品工业科技》青年编委、广东省科协科技成果转化联合体特聘专家等。

研究方向

食品安全快速检测新技术、抗体与小分子药物互作机制

承担教学

《食品营养学》、《分子营养学》、《蛋白质结构与功能》,《食品质量安全认知实习》,《食品营养卫生综合实验》

科研项目

1.国家自然科学基金国际(地区)合作与交流项目,基于保守结构的氟喹诺酮类药物半抗原-抗体选择性识别机制研究及快速免疫分析系统开发,2024/01-2026/12,150万元

2.国家自然科学基金面上项目,以β-激动剂为模型的超高灵敏免疫-CRISPR联合小分子检测系统研究,2021/01-2024/12,58万元

3.十四五国家重点研发计划项目子课题,热加工代谢危害物快速检测预警技术研究,2025/12-2028/11,60万元

4.十四五国家重点研发计划项目子课题,高值动物源性食品现场可视化快速鉴别技术研究,2023/12-2027/12,50万元

5.广东省重点研发计划项目课题,进出口食品中高风险病原菌高效检测方法研究,2025/08-2029/07,110万元

6.广州市科技计划对外科技合作计划,中俄合作动物源食品中药物残留可视化快速检测技术研究与示范应用,2018/04-2021/03,100万元

7.国家自然科学基金青年基金,抗体对映选择性识别手性农药异丙甲草胺的结构基础与分子机制,2017/01-2019/12,20万元

8.华南农业大学青年科技人才培育专项,2016/07-2018/06,20万元

学术论文

1.An Effective Way to Introduce Disulfide Bonds into Nanobodies: Using an Anticarbaryl Nanobody Structure as a Model. Chun-Xiong Liang, Min-Ling Liu, Peng-Yan Guo, Ru-Yu Fang, Olga D. Hendrickson, Anatoly V. Zherdev, Hong Wang, Zhen-Lin Xu, and Xing Shen*. Journal of Agricultural and Food Chemistry, 2026, 74: 19995-20004.

2.Yu Xie, Li Liu, Xue-Ming Cao, Zuo-Qi Gai, Xu Zhang, Hong-Tao Lei, Zhen-Lin Xu,Xing Shen*, A super convenient and specific CRISPR/Cas12a diagnostic platform for toxigenic Burkholderia gladioli based on virulence genes, Food control, 2025, 168: 110904.

3.Yan Liu, Yu Xie, Zhangli Wang, Zuoqi Gai, Xu Zhang, Jiahong Chen, Hongtao Lei, Zhenlin Xu and Xing Shen*. A Simple, Rapid, and Contamination-Free Ultra-Sensitive Cronobacter sakazakii Visual Diagnostic Platform Based on RPA Combined with CRISPR/Cas12a, Foods, 2025, 14: 3120.

4.沈兴,李妍,张旭,盖作启,刘艳,黄颖茵,雷红涛,陈佳虹*.基于CRISPR/Cas系统的免扩增核酸检测技术研究进展,华南理工大学学报(自然科学版),2025.53(1):136-146.

5.Xiaoting Yu, Guohua Zhong, Gang Zhao, Tao Zhou, Jiayi Yu, Xu Zhang, Zuoqi Gai, Zhenlin Xu, Hongtao Lei*,Xing Shen*, Enantioselectivity regulation of antibody against chiral herbicide metolachlor based on interaction at chiral center, International Journal of Biological Macromolecules, 2024, 270: 132471.

6.Xing Shen, Yan Zhang, JingJing Xu, XiaoTing Yu, WenMing Bai, Xinan Huang, and HongTao Lei*, Central Chirality and Axial Chirality Recognition of the Enantioselective Antibodies to Herbicide Metolachlor, Journal of Agricultural and Food Chemistry, 2024, 72: 10055-10064.

7.Jing-Nan Meng, Ze-Ke Xu, Peng-Ru Li, Xi Zeng, Yingju Liu, Zhen-Lin Xu*, Juan Wang, Yu Ding, andXing Shen*, Universal and Naked-Eye Diagnostic Platform for Emetic Bacillus cereus Based on RPA-Assisted CRISPR/Cas12a, Journal of Agricultural and Food Chemistry, 2024, 72: 8823-8830.

8.Peng-Ru Li, Zi-Xuan Wang, Ze-Ke Xu, Juan Wang, Bin Li, Xing Shen,* and Zhen-Lin Xu*. An RPA-Assisted CRISPR/Cas12a Assay Combining Fluorescence and Lateral Flow Strips for the Rapid Detection of EnterotoxigenicBacillus cereus, 2024, 72: 14000-14010.

9.Yuanjun Wen, Shuqin Huang, Hongtao Lei , Xiangmei Li andXing Shen*, A Dual and Rapid RPA-CRISPR/Cas12a Method for Simultaneous Detection of Cattle and Soybean-Derived Adulteration in Goat Milk Powder, Foods, 2024, 13: 1637

10.曹琳彩,文舜华,王凯,刘旭炜,胡卓炎,赵雷,沈兴,重组荔枝类甜蛋白的高效表达、纯化及活性鉴定.食品与发酵工业,2024,50(9):92-98.

11.Jiale Zheng, Li Liu, Xiangmei Li, Zhenlin Xu, Zuoqi Gai, Xu Zhang, Hongtao Lei, Xing Shen*, Rapid and Simple Detection of Burkholderia gladioli in Food Matrices Using RPA-CRISPR/Cas12a Method, Foods, 2023, 12: 1760.

12.Shuqin Huang, Yan Liu, Xu Zhang, Zuoqi Gai, Hongtao Lei, Xing Shen*, A Rapid RPA-CRISPR/Cas12a Detection Method for Adulteration of Goat Milk Powder, Foods, 2023, 12: 1569.

13.Pengyan Guo, Kaiyin Huang, Zijian Chen, Zhenlin Xu, Aifen Qu, Qingchun Yin, Hong Wang, Xing Shen*, Kai Zhou*, A chemiluminescence enzyme immunoassay based on biotinylated nanobody and streptavidin amplifyication for diazinon sensitive quantification, Biosensors, 2023, 13, 577.

14.郭鹏燕,徐振林,陈子键,沈兴.抗杀螟硫磷纳米抗体表达、纯化策略研究及检测方法建立.食品工业科技,2023,44(23):298-305.

15.郑佳乐,何子贤,黎莹莹,江佳丽,李向梅,雷红涛,沈 兴.荧光定量免疫层析法测定鸡肉和牛奶中的氯霉素.食品安全质量检测学报,2023,14(19):20-28.

16.Gang Zhao, Jin Wang, Chanyu Yao, Peichun Xie, Xiangmei Li, Zhenlin Xu, Yanping Xian, Hongtao Lei*, Xing Shen*, Alkaliane lysis-recombinase polymerase amplification combined with CRISPR/Cas12a assay for the ultrafast visual identification of pork in meat products, Food Chemistry, 2022, 383: 132318.

17.Li Liu, Gang Zhao, Xiangmei Li, Zhenlin Xu, Hongtao Lei*, Xing Shen*, Development of rapid and easy detection of Salmonella in food matrics using RPA-CRISPR/12a method, LWT-Food Science and Technology, 2022, 162: 113443.

18.Zeke Xu, Jingnan Meng, Yi Lei, Xingxing Yang, Yiyong Yan, Haihong Liu, Hongtao Lei, Tinggai Wang, Xing Shen*, Zhenlin Xu*, Highly selective monoclonal antibody-based lateral flow immunoassay for visual and sensitive determination of conazole fungicides propiconazole in vegetables, Food Additives & Contaminants: Part A, 2022, 39(1): 92-104.

19.Bo Chen1, Xing Shen1, Zhaodong Li, Jin Wang, Xiangmei Li, Zhenlin Xu, Yudong Shen, Yi Lei, Xinan Huang, Xu Wang, Hongtao Lei, Antibody generation and rapid immunochromatography using time-resolved fluorescence microspheres for propiconazole: fungicide abused as growth regulator in vegetable, Foods, 2022, 11: 324.

20.Xiaoting Yu, Xu Zhang, Jingjing Xu, Pengyan Guo, Xiangmei Li, Hong Wang, Zhenlin Xu, Hongtao Lei*, Xing Shen*, Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters, Journal of Hazardous Materials, 2021, 418: 126305.

21.Lanteng Wang, Wei Xie, Wenyang Jiao, Chijian Zhang, Xiangmei Li, Zhenlin Xu, Xin-an Huang, Hongtao Lei*, Xing Shen*, Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin, RSC Advances, 2021, 11, 39534.

22.Yingying Li, Haihuan Xie, Jin Wang, Xiangmei Li, Zhili Xiao, Zhenlin Xu, Hongtao Lei, Xing Shen*, Lateral Flow immunochromatograohy assay for detection of Furosemide in slimming health foods, Foods, 2021, 10.2041.

23.Jiadong Li, Jun Gai, Minting Ma, Liping Li, Yu Wang, Chenglong Wang, Jinyi Yang, Zhenlin Xu, Min Yao, Xing Shen*, Hong Wang*, Preparation of a Bombyx mori acetylcholinesterase enzyme reagent through chaperone protein disulfide isomerase co-expression strategy in Pichia pastoris for detection of pesticides, Enzyme and Microbial Technology, 2021, 144: 109741.

24.Jin wang1, Xing Shen1, Peng Zhong, Zhaodong Li, Qiushi Tang, Xinan Huang, Anatoly V. Zherdev, Boris B. Dzantiev, Sergei A. Eremin, Zhili Xiao, Hongtao Lei, Xiangmei Li, Heterologous immunoassay strategy for enhancing detection sensitivity of banned dye rhodamine B in fraudulent food, Chemical and Biological Technologies in Agriculture, 2021, 8: 17.

25.Zhenlin Xu; Songling Ye; Luo Lin; Xiude Hua; Jingxian Lai; Xiangping Cai; Qingwen Liang; Hongtao Lei; Yuanming Sun; Yiping Chen; Xing Shen*; Fluores cent enzyme-linked immunoassay based on silane-doped carbon dots for sensitive detection of microcystin-LR in water and crucian samples, Science of The Total Environment, 2020, 709: 134614.

26.Tian Guan; Dayu Liu; Xiangmei Li; Bowen Shu; Menting Li; Yingju Liu; Zhenlin Xu; Yudong Shen; Yuanming Sun; Hongtao Lei*; Xing Shen*; Magnet-actuated droplet microfluidic immunosensor coupled with gel imager for detection of microcystin-LR in aquatic products, Talanta, 2020, 219: 121329.

27.Xing Shen; Jiahong Chen; Shuwei Lv; Xiulan Sun; Boris B. Dzantiev; Sergei A. Eremin; Anatoly V. Zherdev; Jianfa Xu; Yuanming Sun; Hongtao Lei*; Fl uorescence Polarization Immunoassay for Determination of Enrofloxacin in Pork Liver and Chicken, Molecules, 2019, 24(24): 4462-4474.

28.焦文阳,陆宁,王兰腾,关甜,雷红涛,沈兴.凝胶过滤层析一步纯化MC-LR Fab的方法及吸附机制初探.食品工业科技,2019,40(21):84-89.

29.许晶晶,王兰腾,赖玉健,李向梅,雷红涛,沈兴.除草剂异丙甲草胺特异性抗体制备免疫检测方法的建立.现代食品科技,2019,35(10):246-252.

30.Xing Shen, Jiahong Chen, Xiangmei Li, Hongtao Lei, Zhenlin Xu, Yingju Liu, Xinan Huang, Sergei A. Eremine, Cuihua Wu and Aijuan Jia. Monoclonal antibody-based homogeneous immunoassay for three banned agonists and molecular modeling insight, FOOD AND AGRICULTURAL IMMUNOLOGY, 2017, 28 (6): 1438-1449.

31.Xing Shen, Wataru Saburi, Zuoqi Gai, Koji Kato, Teruyo Ojima-Kato, Jian Yu, Keisuke Komoda, Yusuke Kido, Hirokazu Matsui, Haruhide Mori and Min Yao. Structural analysis of the α-glucosidase HaG provides new insights into substrate specificity and catalytic mechanism. Acta Cryst, 2015, D71, 1382-1391.

32.Xing Shen, Wataru Saburi, Zuo-Qi Gai, Keisuke Komoda, Jian Yu, Teruyo Ojima-Kato, Yusuke Kido, Hirokazu Matsui, Haruhide Mori and Min Yao. Crystallization and preliminary X-ray crystallographic analysis of α-glucosidase HaG from Halomonas sp. strain H11, Acta Cryst, 2014, F70, 464-466.

33.Xing Shen, Mei-Rong Chen, Lin Li, and Song-Qing Hu. Expression, Purification, and Functional Analysis of Three Low-Molecular-Weight Glutenin Subunits from Wheat Cultivar Cheyenne. Cereal Chem, 2014, 91 (4): 378-382.

获奖情况

广东省科技进步一等奖,食品真实性鉴别检测关键技术研究与应用,2024.08(排名第2)

专利

1.沈兴,黄颖茵,郑佳乐,雷红涛,赵岗,李向梅,徐振林. CRISPR-免疫联合小分子检测探针制备及检测方法.发明专利,ZL202411207221.6,授权日期:2025.11.11.

2.沈兴,李妍,雷红涛,王璋丽,黄婷婷.一种基于RPA-CRISPR的虹鳟源性成分引物及检测体系和方法.发明专利,ZL202411118478.4,授权日期:2025.10.03.

3.沈兴,谢宇,雷红涛,徐振林,刘艳,朱宇赫.一种基于RPA-CRISPR的唐菖蒲伯克霍尔德氏菌(椰毒假单胞菌酵米面亚种)特异性靶标、引物和检测体系及方法.发明专利,ZL202411143529.9,授权日期:2025.09.26.

4.沈兴,余晓婷,雷红涛,许晶晶,关甜,王锦,李向梅,王弘,徐振林.特异性抗异丙甲草胺碳手性抗体的可变区序列及其重组全长抗体的制备.发明专利,ZL202111678931.3,授权日期:2023.4.7.

5.沈兴,陈博,雷红涛,李向梅,陈佳虹,王锦,徐振林,杨金易,沈玉栋,孙远明.一种丙环唑半抗原、完全抗原和其抗体及其制备和应用.发明专利,ZL202010925563.7,授权日期:2021.9.14.

获得荣誉

2025年华南农业大学教学名师